There really haven't been many heroes from the big two that haven't been killed off and replaced.
Both Barry Allen Flash and Supergirl were killled off in the original Crisis. There have been several Flashes since, including a resurrected Barry Allen, now also rebooted as a much younger man. Several Supergirls, including one that was teamed with Lex Luthor. Several Superboys, Henry Pym even replaced himself when he had a brain snap and married the Wasp when he was YellowJacket.Wolverine? Iron Fist? Batman? [the last several times]