Now that you mention it, major Latino characters are even harder to find than African Americans. The first one that comes to mind is the good old
Cisco Kid (
https://comicbookplus.com/?dlid=31639,
https://comicbookplus.com/?dlid=31640, and many more).
Cisco and Pancho are the granddaddies of comic-book Mexicans. At least Cisco is allowed some good sense along with his flair for the
senoritas. (How do you type a tilde anyway?) Pancho, though...
Then of course there's
Zorro. We don't seem to have him here except in our Spanish language section. By order of the Incredible Disney Monster, I presume. Dell published several Zorro stories in their Four Color series. Later they did a series based on the Disney TV show. All feature predominantly Latino casts.
The Dell adaptation of Zane Grey's
Desert Gold offers both a nasty
bandito and the sympathetic portrayal of an Hispanic woman--married to an Anglo man, surprisingly. (
https://comicbookplus.com/?dlid=62010)
The cover story in
Crack Western #80, "Mexican Massacre," is set in Mexico. It doesn't miss a single offensive stereotype. (
https://comicbookplus.com/?dlid=26010).
A-1 Comics #9 reprints an episode of the humorous Western newspaper strip
Texas Slim, which co-stars a feisty kid named Mexico and features a guest shot by Joaquin Murietta. (
https://comicbookplus.com/?dlid=23952)
In Harvey's
Hi-School Romance #33, a girl vacations in Mexico City where she's stalked by Manuelo, a jai alai player. She falls in love with him and they marry. (
https://comicbookplus.com/?dlid=21135)
We have a couple of UK comics presenting
Pancho Villa as "The Robin Hood of Mexico." (
https://comicbookplus.com/?dlid=28596)
In
The Bouncer #13 One-Round Hogan is almost fleeced by Pedro Martinez, a card sharp who claims to own "the famous Markeeta racetrack in Mexico." Martinez is a crook but at least he doesn't speak with a phony accent. (
https://comicbookplus.com/?dlid=20890)
In St John's
Authentic Police Cases #21, FBI agent Mike Sanchez helps bust a gang smuggling "wetbacks" from Mexico to work in the vineyards. Story title: "Wetbacks for Profit." (
https://comicbookplus.com/?dlid=19086)
EDIT: Ouch! How could I have forgotten
Senorita Rio, the sexy spy who had a long run in Fiction House's
Fight Comics starting with issue #19? Her home base was Brazil. (
https://comicbookplus.com/?dlid=33404 and onward)
These are just books I've happened to run across. I hope they help. We surely have more. I notice that even in unflattering roles American comics featured way more Black characters than Latinos of any sort. Most comic-book Latinos are Mexican nationals. Very few are American-born. Other than Senorita Rio I don't know any featured characters from Central or South America. In comics which openly champion diversity, like
The Challenger and
Taffy), Negroes (their word), Jews, Catholics, and Japanese Americans are identified as persecuted minorities but not Latinos.